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@the-fledgling-artist The easy way to incorporate this character would to make a situation where the other characters need to protect her, since she’s so sickly. Perhaps the evil of this world has an interest in her and would like to kill her or otherwise keep her incapacitated, and her brother feels an obligation to protect her. This could create a lot of tension in the story as the protagonist has to avoid her and the other characters resent the brother’s obligation to protect his sister.

In other words, the evil of the story attacks this character as an attempt to stop the heroes from finishing their quest by strapping them with an obligation to protect her due to the brother’s familial obligation. A hostage situation could also work depending on the needs of the story.